Nucleic acids + 3 other offprints from Scientific American. Signed by Crick. Francis Crick.

Nucleic acids + 3 other offprints from Scientific American. Signed by Crick

Publisher Information: 1954-66.

Crick, Francis H. C. (1916-2004). (1) Nucleic acids. Offprint from Scientific American (September 1957). 8, [4]pp. (2) The structure of the hereditary material. Offprint from Scientific American (October 1954). 7, [1]pp. (3) The genetic code. Offprint from Scientific American (October 1962). 9, [1]pp. (4) The genetic code: III. Offprint from Scientific American (October 1966). 9, [3]pp. Together 4 offprints. Text illustrations. 277 x 211 mm. Original printed self-wrappers. Some unobtrusive pencil notes in the first offprint, ownership stamp (Dietrich Teschner) on the front wrappers of the last three offprints. Signed by Crick on the front wrappers of each offprint. Fine.

First Editions, Offprint Issues of these four papers. “Nucleic acids,” published in the Scientific American in September 1957, is based on Crick’s famous “Central Dogma” lecture given in the same month. The Scientific American article, which appeared a year before his paper “On protein synthesis,” contains the first published appearance of Crick’s famous term describing a fundamental property of genetics:

"This . . . illustrates very well what my colleagues and I call the Central Dogma: namely, that once information (meaning here the determination of a sequence of units) has been passed into a protein molecule it cannot get out again, either to form a copy of the molecule or to affect the blueprint of a nucleic acid" (p. [9]).

“Crick’s talk is now often called the ‘central dogma’ lecture, for it was here that he first publicly presented this frequently misunderstood concept. While this was highly significant, the content of the lecture was even richer—it also saw Crick outline his view of the nature of life and of genetic information and the source of protein folding as well as making two bold and spectacularly accurate predictions: that there must exist a small ‘adaptor’ molecule (now known as tRNA) that could bring amino acids to the site of protein synthesis and that in the future, scientists would be able to explore rich evolutionary sources of information by comparing sequence data. In this one brief lecture, Crick profoundly influenced how we think. In The Eighth Day of Creation, journalist Horace Judson went so far as to claim that on that day 60 years ago, Crick ‘permanently altered the logic of biology’” (M. Cobb, “60 years ago Francis Crick changed the logic of biology,” PLOS Biology [2017] 10.1371/journal.pbio.2003243).

The third offprint in this group, “The genetic code,” presents in a somewhat more popular vein the researches described in Crick’s “General nature of the genetic code for proteins” (1961), co-written with L. M. Barnett, Sydney Brenner and R. J. Watts-Tobin; see 256.8. 13097. M. Cobb, Life’s Greatest Secret: The Race to Crack the Genetic Code (2015), ch. 8.

Book Id: 46093

Price: $7,500.00

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