Publisher Information: 1907.
First Account of Microbial Drug Resistance
Ehrlich, Paul (1854-1915). Chemotherapeutische Trypanosomen-Studien. Offprint from Berliner klinischen Wochenschrift, no. 9-12 (1907). 42pp. 222 x 145 mm. Original printed wrappers, slightly toned and chipped, small split in lower spine. Very good copy. Presentation Copy, inscribed by Ehrlich on the front wrapper: “H. Prof. Dr. Kamell(?) in [. . .] hochachtung P. Ehrlich.” Stamp of the Johns Hopkins Medical School Library.
First Edition, Offprint Issue. The first account of induced microbial drug resistance, a now widespread phenomenon that has become a major concern for physicians and the pharmaceutical industry. Ehrlich encountered induced drug resistance in microbes while researching arsenical preparations as cures for sleeping sickness and other trypanosome-caused illnesses. His paper, delivered as a lecture on Feb. 13, 1907, “explained how the widely varying stains of trypanosomes, which at first reacted with great sensitivity to chemotherapeutic agents, gradually became drug resistant and how this property was passed on to their offspring for many generations” (Bäumler, Paul Ehrlich, p. 128). Ehrlich continued to investigate drug-resistant trypanosomes for several years, recognizing that resistance provided an important tool for studying mechanisms of immune response. This copy bears a presentation inscription in Ehrlich’s bold hand; we have not been able to identify the recipient. Franklin and Snow, Biochemistry and Molecular Biology of Antimicrobial Drug Action, p. 135. Gradmann, “Magic bullets and moving targets: Antibiotic resistance and experimental chemotherapy, 1900-1940,” Dynamis 31 (2011).Book Id: 43157