Publisher Information: 1879-1912. First edition.
Miescher's Copies of Kossel's papers on Nucleic Acids
Kossel, Albrecht (1853-1927). (1) Zur Chemie des Zellkerns. Offprint from Zeitschr. phys. Chem. 7 (1882). 7-22pp. Original printed wrappers. (2) Weitere Beiträge zur Chemie des Zellkerns. Offprint from Zeitschr. phys. Chemie 10 (1886). 248-264pp. Original printed wrappers, vertically creased. (3) 14 offprints detailing Kossel's researches on nucleins (nucleoproteins), as listed below. 1879-1912. See list for condition details. One of the offprints (no. 13 below) is signed by Kossel; 8 of the offprints bear the booklabel and stamp of Johann Friedrich Miescher (1844-95), discoverer of nuclein; see G-M 695.
First Editions, Offprint Issues. G-M 702 (nos.  and ). Kossel was awarded the Nobel Prize in 1910 "in recognition of the contributions to our knowledge of cell chemistry made through his work on proteins, including the nucleic substances" (Nobel E-Museum). His researches on "nucleic substances" represent some of the early stages in the development of molecular biology.
In 1869 J. F. Miescher, then working in Felix Hoppe-Seyler's biochemical laboratory in Tübingen, discovered in the cell nucleus an acid-insoluble, alkali-soluble, high-phosphorus containing substance that he named nuclein; we now know it as DNA. Kossel's researches on nuclein, begun ten years after Miescher's discovery, led to the development of reliable methods for isolating, purifying and analyzing the nucleus, identification of the chemical makeup of nuclein, and the discovery of the nitrogen bases adenine, thymine, cytosine and uracil, familiar to us now as some of the fundamental components of DNA and RNA (guanine, the remaining DNA nitrogen base, had been discovered previously). Kossel and his students working in Berlin:
"demonstrated that these, together with xanthine, hypoxanthine, and guanine (sarcine), are breakdown products of nucleic acids, which can be used to distinguish between the true nucleins of the cell nucleus and the spurious nucleins found in milk and egg yolk, which he termed "paranucleins." . . . From physiological studies Kossel correctly concluded that the function of nuclein is neither to act as a storage substance nor to furnish energy for muscular contraction; rather, it must be associated with the formation of fresh tissue [i.e. the production of proteins] "(DSB).
By the end of the nineteenth century, Kossel had characterized nucleins as unique substances-acidic substances, for which Richard Altmann introduced the term "nucleic acid" in 1889. Our collection of offprints includes seven of the papers on nucleins cited in the DSB's article on Kossel (nos. 1, 2, 3, 4, 5, 6, 8 below), plus two of the three papers cited as Garrison-Morton 702 (nos.  and  above).
Kossel never specifically linked his work on nucleic acids to heredity, but he was aware of their general role in the production of proteins. After his receipt of the Nobel Prize he speculated publicly on the source of biological specificity, particularly in his Herter Foundation lecture (no. 14 below), in which he "clearly recognized the potential diversity of polypeptides and saw in the structure of proteins the chemical basis of biological specificity"(DSB).
Eight of the offprints in this collection bear the ownership marks of Miescher, whose discovery of nuclein in 1869 is referenced above. Both Miescher and Kossel had been students of Felix Hoppe-Seyler, a founder of the science of physiological chemistry. Magill, Nobel Prize Winners (phys. & med.), pp. 139-47. Wolf, "Friedrich Miescher, the man who discovered DNA" (internet reference)
1. Ueber das Nuclein der Hefe. Erster Theil. Offprint from Zeitschr. phys. Chemie (1879). 284-291pp. Orig. printed self-wrappers. Light soiling and creasing. Miescher's stamp and booklabel.
2. Ueber das Nuclein der Hefe. Zweiter Theil. Zeitschr. phys. Chemie 4 (1880). 290-295pp. Orig. printed self-wrappers. Some spotting. Miescher's stamp and booklabel.
3. Ueber die Herkunft des Hypoxanthins in den Organismen. Offprint from Zeitschr. phys. Chemie 5 (1881). 152-156pp. Original printed self-wrappers. Light spotting and creasing. Miescher's stamp and booklabel.
4. Ueber einen peptonartigen Bestandtheil des Zellkerns. Offprint from Zeitschr. phys. Chemie 8 (1884). 511-515pp. Original printed wrappers, creased vertically.
5. Ueber das Adenin. Offprint from Zeitschr. phys. Chemie 12 (1888). 241-253pp. Original printed wrappers, vertically creased. Miescher's booklabel and stamp.
6. Ueber die chemische Zusammensetzung der Zelle. Offprint from Verhandl. phys. Gesellsch. z. Berlin (1890-91). 7pp. Without wrappers. Miescher's stamp and booklabel.
7. Ueber einige Bestantheile des Nervenmarks. Offprint from Verh. phys. Gesellsch. z. Berlin (1890-91). 8pp. Without wrappers. Miescher's stamp and booklabel.
8. Ueber die Nucleinsäure. Offprint from Verh. phys. Gesellsch. z. Berlin (1892-93), no. 1. 8pp. Without wrappers. Miescher's booklabel and stamp.
9. Weitere Beiträge zur Kenntniss der Nucleinsäure. Offprint from Verh. phys. Gesellsch. z. Berlin (1893-94). 11pp. Without wrappers.
10. (With Albert Neumann). Über die Spaltungsproducte der Nucleinsäure. Offprint from Sitz. k. preuss. Akad. Wissensch. Berlin 18 (1894). 7pp. Original printed wrappers. Miescher's stamp and booklabel.
11. Über die basischen Stoffe des Zellkerns. Offprint from Sitz. k. preuss. Akad. Wissensch. Berlin 18 (1896). 6pp. Original printed wrappers, a little creased.
12. Ueber die Eiweissstoffe. Offprint from Deutschen Med. Wochenschr. (1898), no. 37. 6pp. Without wrappers. Light toning, small tears in upper left corners of leaves. G-M 721.
13. Ueber die chemische Beschaffenheit des Zellkerns. Offprint from Münchener med. Wochenschr. (1911). 14pp. Original printed wrappers. Inscribed by Kossel on the front wrapper.
14. Lectures on the Herter Foundation. Offprint from Johns Hopkins Hosp. Bull. 23 (1912). 34pp. Original printed wrappers.Very Good. Book Id: 40021