Publisher Information: Paris: 1809.
(1) Examen de l’action de quelques végétaux, sur la moelle épinière . . . - Offprint from Bulletin du Société philomathique 1 (1809). 22pp. (2) Expériences pour servir à l’histoire de la transpiration pulmonaire. Offprint from Bulletin du Société philomathique 2 (1811). 3-20pp. (3) Mémoire sur les organs de l’absorption chez les mammifères. Offprint from Bulletin du Société philomathique (1809). 16pp. Together 3 works in 1, 8vo. 204 x 125 mm. Quarter morocco, marbled boards in period style. Light toning, otherwise fine.
First Separate Editions. Extremely rare offprints of some of Magendie’s first experimental papers. The first paper, which marks the foundation of experimental pharmacology, describes the effects on the spinal cord of the Javanese plant “upas tieute” (of the strychnos group); the third examines the absorption of poisons in mammals. They represent the first records of attempts to administer chemical substances to living organisms in a systematic way so that the effects of similar chemical agents from different sources may be compared. Magendie reprinted the “Mémoire sur les organs de l’absorption” in the first volume of his Journal de physiologie expérimentale (1821), noting that he had found nothing to alter in it even after the passage of eleven years since its first publication. The second paper is Magendie’s memoir on the loss of water from the lungs.
"In 1809 Magendie presented to the Académie des Sciences and to the Société Philomatique the results of his first experimental work, which he carried out in collaboration with the botanist and physician Alire Raffeneau-Delille. In a series of experiments on various animals the two investigators studied the toxic action of several botanic drugs, particularly upas, nux vomica, and St.-Ignatius's bean. These experiments marked the beginning of experimental pharmacology. They were the first experimental comparisons of the similar effects produced by drugs of different botanical origin.
Book Id: 13355
"Magendie believed that the toxic or medicinal action of natural drugs depends on the chemical substances they contain, and that it be would to obtain these substances in the pure state. As early as 1809 he suspected the existence of strychnine, later isolated, in accord with his predictions, by Pierre Joseph Pelletier in 1819. Moreover, in 1817, in collaboration with Pelletier, Magendie discovered emetine, the active principle of the root of Carapichea ipecacuanha or ipecac" (Garrison-Morton.com 9578). Olmsted, Magendie, pp. 35-47; he does not cite these offprints in his bibliography, and notes only the 1821 reprint of the “Mémoire.”